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Primary Cells Collection

Primary Cells: HMEpC (830-05a)

Catalogue No.: 06090747
CAI No.: 830-05a
Cell Line Name: HMEpC (830-05a)
Species: Human
Tissue: Breast
Cell Line Description: Human Mammary Epithelial Cells (HMEpC) are derived from normal adult mammary glands. They are cryopreserved at fifth passage. HMEpC can be cultured and propagated 16 population doublings. It was shown that normal HMEpC have a high amount of cyclin-dependent kinase 6 activity, which restrains HMEpC proliferation, and loss or down-regulation of cdk 6 may play a role in breast tumor development(1). Transforming HMEpC to immortality and malignancy was a useful model for studying early breast carcinogenesis(2). Autocrine colony-stimulating factor receptors may contribute to invasive progression in epithelial cancer was demonstrated in a 3-dimensional culture of HMEpC(3). References:1.Lucas, J.J. et al, Mol. Cancer Res. 2(2):105 (2004). 2.Stampfer, M.R. et al, J. Mammary Gland Biol. Neoplasia 5(4):365 (2000). 3.Wrobel, C.N. et al, J. Cell Bio.165(2):263 (2004). Characterization: Typical epithelial cell morphology.
Subculture Routine: Refer to 'Instructions for Culturing' document
Culture Medium: Human Mammary Epithelial Cell Growth Medium (815K-500) cat no. 06091524
Depositor: Cell Applications Inc. (CAI), San Diego, USA
Originator: Yes
Country: USA
References: None Specified By Depositor
Release Conditions: No

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