Culture Collections

International Cell Line Authentication Committee (ICLAC)

Raising Awareness of Cell Line Misidentification

In 2012 ECACC co-founded the International Cell Line Authentication Committee (ICLAC). ICLAC aims to ensure that cell line misidentification has a much higher profile and promote awareness of the adverse scientific consequences. In addition to ECACC, ICLAC members also include representatives from other international cell culture collections and respected scientific researchers committed to championing the importance of verified cell line identity.

There are documented cases where researchers have unwittingly used a cell line claimed to represent one type of tissue which has subsequently been found to be from another tissue and/or individual. One of the consequences has been the retraction of scientific publications; in some cases delays to the progress of drug development have arisen. It is estimated that 15 – 20% of cancer research publications are based on work using misidentified cell lines1.

ICLAC evolved from the global committee that published a standard (American National Standards Institute [ANSI] ASN-0002) for the authentication of cell lines and now administers and publishes the internationally-recognised database of misidentified cell lines.

As understanding of this issue grows, an increasing number of researchers are opting to source authentic cell lines and use the cell line authentication services offered by ECACC.

 

References

1. Freshney R. I. (2010) Database of misidentified cell lines. Int J Cancer. 126: 302-04

 

 

 

 

 

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