Culture Collections

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ECACC supports Motor Neurone Disease research*

 MND Poster Image

 

The UK Motor Neurone Disease (MND) Association has acknowledged the contribution of PHE’s European Collection of Cell Cultures (ECACC) genetic support services to the UK MND DNA Bank.  The work of the DNA Bank to facilitate genetic research into all forms of MND was presented in a poster at the 24th International Symposium on Amyotrophic Lateral Sclerosis (ALS) / MND in Milan, Italy on 8th December 2013.  ECACC has generated thousands of cell lines from donor blood samples collected by the bank.  Each cell line provides a renewable source of DNA.  Whereas a blood sample is a finite resource; once depleted it is necessary to return to the donor.  Continuous cell lines can be cultured indefinitely.

Established in 2003, the MND DNA bank is a repository of DNA and clinical information collected from people with MND and their family members.  This is an invaluable resource for the international MND research community carrying out studies into the genetic basis of all forms of motor neurone disease.  It is administered by the Motor Neurone Disease Association.

The poster shows how samples are acquired, processed and stored.  This includes the blood processing work and generation of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines by ECACC.  Examples of published research work using the DNA bank samples for gene expression profile studies, genome wide association studies, copy number variation and homozygosity mapping are cited.

 

Poster:  UK MND DNA Bank:  A repository of DNA and clinical information for the International MND Research Community (opens in new window)

To apply for samples from the MND DNA bank, please contact the MND Association

For specific enquiries about the genetic support services offered by ECACC contact us.

 

Additional Information

Overview of the Genetic Support Services provided by ECACC

Generation of EBV-transformed lymphoblastoid cell lines

DNA Extraction Service - from whole blood and cell lines

The importance of cell lines in genomics research

 

Published December 2013

 

*For up to date information on the MND Collections Cell lines visit Introducing the MND Collections Cell lines May 2018

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