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The European Bank for induced Pluripotent Stem Cells (EBiSC) is a centralised, non-profit repository and distribution hub for long term storage of deposited human induced pluripotent stem cell (iPSC) lines and their distribution to academic and commercial researchers worldwide. Since 2015, more than 19 researchers across Europe and America have shared iPSC lines with EBiSC, including >35 disease areas (e.g. cardiac, neurodegenerative, neurological, metabolic, haematological and eye disorders) and familial and isogenic controls. Over the last few months, key EBiSC partners have been working hard on supporting local COVID response efforts in addition to restricting non-essential work across all central biobanking sites to try and help slow spread of the disease. However as things start returning to normal – so is EBiSC with priority iPSC line banking, QC and distribution now in progress.

A robust operational framework including Fraunhofer-IBMT and ECACC as core banking partners ensures cost-efficient collection, qualification and iPSC line distribution. Rigorous review criteria ensure appropriate consent collection and clear communication of use restrictions, if present. A robust quality control screening regime ensures that iPSC lines from varying sources perform comparably in the hands of users and are of a high quality and integrity. The human Pluripotent Stem Cell Registry (hPSCreg) streamlines iPSC line data management. All data is publically available prior to purchase via the EBiSC website, with genomic datasets available through application to a data access committee. Users access EBiSC iPSC lines through a simplified access procedure allowing them to source iPSC lines from multiple sources simultaneously under a single access agreement.

EBiSC’s second project phase (currently in progress) guides iPSC research projects from early phases onwards to design a project framework with clarity on iPSC ownership, support with biosample collection and guidance on advised QC at critical time points. Additionally, EBiSC2 assists iPSC researchers in iPSC reprogramming, gene-editing and custom banking and QC.

 Written by Rachel Steeg, The European Bank for induced Pluripotent Stem Cells (EBiSC) 

September 2020

 

Further information

The European Bank for induced Pluripotent Stem Cells (EBiSC)

The human Pluripotent Stem Cell Registry (hPSCreg)

 

 

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