The European Bank for induced pluripotent Stem Cells (EBiSC) launched a second project phase in 2019 to become a self-sustainable repository for human induced pluripotent stem cells (hiPSC), extend the existing cell catalogue, and offer additional hiPSC-related services.
Several articles have subsequently been published on topics such as the generation of isogenic, gene-edited iPSC lines in Alzheimer's disease research, the Human Pluripotent Stem Cell Registry (hPSCreg) and its role in registration of pluripotent cell lines and EBiSC as a cell line bank for disease studies:
Alzheimer's disease (AD) is the most frequent neurodegenerative disease amongst the elderly. The SNPs rs429358 and rs7412 in the APOE gene are the most common risk factor for sporadic AD, and there are three different alleles commonly referred to as APOE-ε2, APOE-ε3 and APOE-ε4. Induced pluripotent stem cells (iPSCs) hold great promise to model AD as such cells can be differentiated in vitro to the required cell type....
The European Bank for induced Pluripotent Stem Cells (EBiSC), a non-profit repository for storage, banking, Quality Control (QC) and subsequent distribution of research-grade human induced Pluripotent Stem Cell (iPSC) lines, has centralised iPSC lines generated internationally across >35 disease areas and made them available to users via the EBiSC Catalogue, for research use (cells.ebisc.org/)....
The value of human pluripotent stem cells (hPSC) in regenerative medicine has yet to reach its full potential. The road from basic research tool to clinically validated PSC-derived cell therapy products is a long and winding one, leading researchers, clinicians, industry and regulators alike into undiscovered territory.....
Steeg, Rachel et al., 2020. The EBiSC iPSC bank for disease studies. Stem cell research, 49, pp.Stem cell research, 2020–12, Vol.49. https://doi.org/10.1016/j.scr.2020.102034
Mah, Nancy et al., 2020. Access to stem cell data and registration of pluripotent cell lines: The Human Pluripotent Stem Cell Registry (hPSCreg). Stem cell research, 47, p.101887. https://doi.org/10.1016/j.scr.2020.101887
Schmid, Benjamin et al., 2019. Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line. Stem cell research, 34, p.101349. https://doi.org/10.1016/j.scr.2018.11.010
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