Culture Collections

New accessions coming soon: new ‘paired’ normal and transformed breast, ovarian, and fallopian tube cell lines

 

Xenograft 3

 

Coming soon to the ECACC General Collection are 47 new cells lines from human Ovary, Breast and Fallopian Tube tissue samples. These cell lines will be a great addition to the collection as they offer paired cell lines from a ‘normal’ and ‘engineered’ diseased state (transformed and tumorigenic).

The cell line collections fall into four distinct categories:

• Human Ovarian cell lines
• ‘Engineered’ normal immortalized Ovary, Fallopian Tube and Breast cell lines
• ‘Engineered’ transformed Ovary, Fallopian Tube and Breast cell lines
• ‘Engineered’ tumorigenic Ovary, Fallopian Tube and Breast cell lines

The new Ovarian Cancer cell line collection is a valuable resource for the study of ovarian cancers and therapeutic development for their treatment, providing a greatly improved platform for in vitro and xenograft based investigations into high-grade, poorly differentiated ovarian cancers.

The ‘normal’ and ‘engineered’ Ovarian and Fallopian Tube cell line collection came from patients aged 56 and 65 and were taken from patients undergoing surgery for benign gynaecologic conditions (Accession Numbers 20012016 – 20012026).

The Breast Epithelial cell line collection were established from patients who were classed as disease free reduction mammoplasties and were aged between 26 and 48 years old (Accession Numbers 20012027 – 20012047).

Deposited from the lab of Dr Tan A Ince, formerly of the University of Miami, FL, USA, these cell lines were initially collected and developed at the Brigham and Women’s Hospital, Boston, MA, USA and fall under the IRB Approval Protocol#: 2005-P-001862/1); in which the research activities in the proposal did not meet the definition of human subjects. All samples were taken from surgically discarded tissue.

The following cell lines are coming soon:

 

Accession number Cell line name
20012001  OCI-C1p cell line
20012002  OCI-C4p Cell Line
20012003  OCI-C5x Cell Line
20012004  OCI-P2a Cell Line
20012005  OCI-P5x Cell Line
20012006  OCI-P7a Cell Line
20012007 OCI-P8p Cell Line
20012008  OCI-P9a1 Cell Line
20012009  FCI-P2p Cell Line
20012010  OCI-CSp Cell Line
20012011  OCI-U1a Cell Line
20012012  OCI-E1p Cell Line
20012013  OCI-EP1p Cell Line
20012014  OCI-M1p Cell Line
20012015  OCI-P9a2 Cell Line
20012016  OCE1 Cell Line
20012017  OCLE1 Cell Line
20012018  OCLER1 Cell Line
20012019  OCE2 Cell Line
20012020  OCLE2 Cell Line
20012021  FNE1 Cell Line
20012022  FNLE1 Cell Line
20012023  FNLER1 Cell Line
20012024  FNLER1 Cell Line
20012025  FNE2 Cell Line
20012026  FNLE2 Cell Line
20012027  FNLER2 Cell Line
20012028  BPE1 Cell Line
20012029  BPLE1 Cell Line
20012030  BPLER1 Cell Line
20012031  BPE2 Cell Line
20012032  BPLE2 Cell Line
20012033  BPLER2 Cell Line
20012034  BPE3 Cell Line
20012035  BPLE3 Cell Line
20012036  BPE4 Cell Line
20012037  BPLE4 Cell Line
20012038  BPLER4 Cell Line
20012039  HME2 Cell Line
20012040  HMLE2 Cell Line
20012041  HMLER2 Cell Line
20012042  HME3 Cell Line
20012043  HMLE3 Cell Line
20012044  HMLER3 Cell Line
20012045  HME4 Cell Line
20012046  HMLE4 Cell Line
20012047  HMLER4 Cell Line

 

 

Written by Simone Lilley, Gywain Jones and Alastair Handley

July 2020

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