Culture Collections

Bacteria and Mycoplasmas detail

Conditions of Supply of Microbial Pathogens: Safety

Bacteria Collection: streptococcus mitis

NCTC Number: NCTC 10712
Current Name: streptococcus mitis
Original Strain Reference: FW 75
Other Collection No: FW 75
Previous Catalogue Name: Streptococcus sp. viridans type
Type Strain: No
Family: Streptococcaceae
Hazard Group (ACDP): 2
Release Restrictions: Terms & Conditions of Supply of Microbial Pathogens: Safety
Conditions for growth on solid media: Blood agar, 37, facultative anaerobe
Conditions for growth on liquid media: nutrient broth, 37, facultative anaerobe
Isolated From: human, sputum ;1962
Bibliography: COLMAN G 1969 J.GEN.MICROBIOL. 57 247;COLMAN G 1968 J.GEN.MICROBIOL. 50
Extended Bibliography: showhide Show bibliography
Ref #: 95509
Author(s): Majewski,J.;Zawadzki,P.;Pickerill,P.;Cohan,F.M.;Dowson,C.G.
Journal: J Bacteriol
Title: Barriers to genetic exchange between bacterial species: Streptococcus pneumoniae transformation
Volume: 182
Page(s): 1016-23
Year: 2000
Keyword(s): GENBANK/AF194507 GENBANK/AF194508 GENBANK/AF194509 GENBANK/AF194510 GENBANK/AF194511 GENBANK/AF194512 GENBANK/AF194513 GENBANK/AF194514 GENBANK/AF194515 GENBANK/AF194516 GENBANK/AF194517 GENBANK/AF194518 GENBANK/AF194519 GENBANK/AF194520 GENBANK/AF194521 GENBANK/AF194522 GENBANK/AF194523 GENBANK/AF194524 GENBANK/AF194525 GENBANK/AF194526 GENBANK/AF194527 GENBANK/AF194528 Base Pair Mismatch/*genetics DNA Repair/*genetics DNA, Bacterial/genetics DNA-Directed RNA Polymerases/genetics Molecular Sequence Data Phylogeny Recombination, Genetic Sequence Analysis, DNA Streptococcus/genetics Streptococcus pneumoniae/*genetics/growth & development *Transformation, Bacterial
Remarks: Interspecies genetic exchange is an important evolutionary mechanism in bacteria. It allows rapid acquisition of novel functions by transmission of adaptive genes between related species. However, the frequency of homologous recombination between bacterial species decreases sharply with the extent of DNA sequence divergence between the donor and the recipient. In Bacillus and Escherichia, this sexual isolation has been shown to be an exponential function of sequence divergence. Here we demonstrate that sexual isolation in transformation between Streptococcus pneumoniae recipient strains and donor DNA from related strains and species follows the described exponential relationship. We show that the Hex mismatch repair system poses a significant barrier to recombination over the entire range of sequence divergence (0.6 to 27%) investigated. Although mismatch repair becomes partially saturated, it is responsible for 34% of the observed sexual isolation. This is greater than the role of mismatch repair in Bacillus but less than that in Escherichia. The remaining non-Hex-mediated barrier to recombination can be provided by a variety of mechanisms. We discuss the possible additional mechanisms of sexual isolation, in view of earlier findings from Bacillus, Escherichia, and Streptococcus.
URL: 10648528
Data: G. Colman, London in 1970 / Sputum / G. Colman (pers. comm. ) considers this strain to correspond to the description of Streptococcus mitior / Colman, G. (1968) J. gen. Microbiol. 50, 149; (1969) 57, 247
Variety: variety viridans
Accession Date: 01/01/1970
Depositor: COLMAN G
Taxonomy: TaxLink: G2819 (Streptococcus Rosenbach 1884) - Date of change: 5/02/2003
Biosafety Responsibility: It is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country

Additional Information

Note: Links open in a new window


The Culture Collections hold cell cultures, bacteria, fungi and virus strains from worldwide sources. Our scientists ensure that the identification of the cultures is correct and they remain unchanged from when they are first deposited with the Collection. Nevertheless, some of the data we provide about the cultures is supplied by the person depositing the strains and, although we have multiple checking procedures in place, we cannot always verify all their data. Please note that the Culture Collections cannot be held responsible for any inaccuracies in the data provided by the depositors.

Cultures supplied by Culture Collections are to be used as controls for microbiology testing and for research purposes only. Please view the Terms & Conditions of Supply for more information.

Contact us if you want to discuss commercial use of the cultures.

Available Formats

Ampoule (Bacteria)

Back to top
Copyright © Public Health England.

Please confirm your country of origin from the list below.