Managed by the Motor Neurone Disease (MND) Association, the MND Collections Cell lines are easily accessible to researchers studying MND and developing new treatments.
Between 2003 and 2012 the MND Association collected over 3,000 blood samples from people with MND, their families and spouse controls. These samples are stored as DNA (stored at the Centre for Integrated Genomic Medical Research (CIGMR) at the University of Manchester) and a subset of these are available as EBV-transformed lymphocytes stored at Public Health England’s Culture Collections.
Cell lines and data
In 2015 the MND Association carefully selected 193 of these transformed cell lines to create larger, fully authenticated, quality tested cell banks. The cell lines selected were created from people with the rare, inherited form of MND, also known as ‘familial MND’.
All of the samples are accompanied by a minimum data set, and most samples have much more comprehensive data associated with them, including medical test results and MND-specific functional rating scales (eg ALSFRS-r).
Role of ECACC
Our role in the project, as the European Collection of Authenticated Cell Cultures (ECACC), is to create and maintain these banks. Although the entire collection of over 2,900 MND cell lines is available to researchers, these 193 selected lines provide the starting block for researchers working in the field of MND research.
Accessing cell lines
The MND Association is the custodian of this collection and all requests to access the samples must be ratified by their Biomedical Research Advisory Panel. Please use the following pages to browse the collection, and pick a potential sample list. Once you’ve selected your samples and submitted your order to ECACC, the MND Association will be in contact to discuss the application process.
Other cell lines are available that are not included in the familial range (including those from people with sporadic MND), please make enquiries directly to the MND Association to access these. More information on the MND Collections Cell lines is available on the MND Association’s website: www.mndassociation.org/mndcollections
Cell lines in the MND Collections are free of charge; however, there is an administration fee of £75 per order and routine shipping costs apply.
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