Culture Collections

Use of NCTC 3000 WGS data to evaluate bioinformatics tool, HINGE

NCTC 3000 is a collaborative whole genome sequencing project being undertaken jointly between the Culture Collections of Public Health England and the Wellcome Trust Sanger Institute. This Wellcome Trust funded project aims to sequence the genomes of 3,000 type and reference strains of bacteria from NCTC. Recently data from the project was used to evaluate and assess a new long read bioinformatics assembling tool for repeat resolution within sequences obtained, named HINGE.

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Mouse cDNA from ECACC

One common question which regularly appears in the ECACC technical enquiries box is: “Do you have a cell line that expresses our gene of interest?”  Sometimes a literature search provides the answer but more often experimental investigation is needed.   Messenger RNA (mRNA) analysis can assess the gene expression of cell lines. Typically a researcher would isolate total RNA from the cell lines under review and convert this to complimentary DNA (cDNA) using reverse transcription.

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South American Zika Virus strain now available for research

The National Collection of Pathogenic Viruses (NCPV) is pleased to announce the availability of a South American Zika virus strain for the international research community.  As part of the response to the Public Health Emergency of International Concern, Culture Collections of Public Health England has collaborated with the US Centers for Disease Control and Prevention (CDC), to make an isolate of the virus, derived from the current outbreak in South America.

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Why Choose Us?

Public Health England (PHE) operates four unique collections consisting of expertly preserved, authenticated cell lines and microbial strains of known provenance for use in medical science and laboratory healthcare.

Cultures from the PHE collections are used by scientists who need to reassure themselves and others that the materials they are using are authentic, so the conclusions to their studies are valid and relevant.


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Cell lines

The European Collection of Authenticated Cell Cultures (ECACC) maintains and supplies over 40,000 cell lines and their derivatives such as DNA, RNA and cDNA.





The National Collection of Type Cultures (NCTC) maintains and supplies over 5000 bacteria and mycoplasma strains.





The National Collection of Pathogenic Viruses (NCPV) maintains and supplies over 700 viruses and viral nucleic acid.





The National Collection of Pathogenic Fungi (NCPF) maintains and supplies over 4000 fungal strains.


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